Study on the Mechanism of Soothing Liver Mixture against Liver Injury induced by Antituberculosis Drugs through Lipopolysaccharide/Toll-Like Receptor 4/Nuclear Factor Kappa B Signal Pathway

Based on plasma endotoxin/toll-like receptor-4/nuclear factor-kappa B signal pathway to investigate the protective effect of soothing liver mixture mice with injury induced by antituberculosis drugs. A total 72 Sprague Dawley male rats were randomly divided into blank control group, model silymarin group and (low, medium high dosage), 12 in each group. 16 h after last administration, pathological changes tissue observed hematoxylin eosin staining; blood samples taken from eyeball detect function indexes (alanine aminotransferase, aspartate alkaline phosphatase) oxidative stress (superoxide dismutase, malondialdehyde, glutathione peroxidase) inflammatory factors (interleukin- 1beta, interleukin-6, tumor necrosis factor-alpha) content endotoxin plasma; microRNA expression levels toll-like receptor-4 nuclear rat detected real time reverse transcription–polymerase chain reaction. Soothing can alleviate hepatocyte injury, effectively improve rats, attenuate reactions body, reduce inhibit hepatic factorkappa protein expression, higher drug dose, better was similar dose efficacy. has a drugs; mechanism may involve regulation signaling alleviation body's